We talked about lemons and metabolism a few years ago - you can read the post http://www.lose-weight-feel-great.com/2006/12/17/e-mail-question-does-lemon-juice-boost-metabolism/.  But there is still a lot of questions around whether lemons can help increase metabolism.

Doing some new research on the web, I found this information which may help our visitors.  The information is very technical in nature, as it was meant for other researchers and doctors.  Emphasis is mine of what I thought are keypoints from the abstract – but remember, I’m not a doctor and am not really in a position to provide my opinion on the study or whether this would work for you.

The study below was done on mice – not on humans.  I spent several hours searching for any clinical trials on humans, however large or small and was not able to find any information.

The aim of this study was to investigate the effect of dietary lemon polyphenols on high-fat diet-induced obesity in mice, and on the regulation of the expression of the genes involved in lipid metabolism to elucidate the mechanisms. Mice were divided into three groups and fed either a low fat diet (LF) or a high fat diet (HF) or a high fat diet supplemented with 0.5% w/w lemon polyphenols (LP) extracted from lemon peel for 12 weeks. Body weight gain, fat pad accumulation, the development of hyperlipidemia, hyperglycemia, and insulin resistance were significantly suppressed by lemon polyphenols. Supplementation with lemon polyphenols also significantly up-regulated the mRNA level of the peroxisome proliferator activated receptor-? (PPAR?) compared to the LF and HF groups in the liver. Furthermore, the mRNA level of acyl-CoA oxidase (ACO) was up-regulated in the LP group compared to the LF group, but not HF group in the liver, and was also significantly increased in the epididymal white adipose tissue. Thus, feeding with lemon polyphenols suppressed body weight gain and body fat accumulation by increasing peroxisomal ?-oxidation through up-regulation of the mRNA level of ACO in the liver and white adipose tissue, which was likely mediated via up-regulation of the mRNA levels of PPAR?.

Read the full article at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2581754

Here is to your health!

Mohamed

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